ABSTRACT
Kaposi Sarcoma is a low-grade malignant mesenchymal neoplasm commonly associated with acquired immunodeficiency syndrome (AIDS). It primarily affects the cutaneous layer of the face and extremities and also oropharyngeal mucosa. Involvement of the larynx is somewhat unusual, with sparse information in the English literature. Herein, the author reported a case of a 27-year-old gentleman with Human immunodeficiency virus (HIV) on HAART treatment, who presented with progressive dysphonia and globus sensation of 1-month duration. In addition to the multiple purplish raised papules over his right forearm, a similar violaceous lesion was observed arising from the lingual surface of the epiglottis via flexible bedside laryngoscopy. Biopsy of the lesions confirmed the diagnosis of Kaposi Sarcoma. The clinical conundrum of managing this case was well illustrated with the concurrent diagnosis of COVID-19 in him. Detailed counselling on the treatment options of the laryngeal lesion was arranged, involving a multidisciplinary approach. The patient then opted for concurrent chemoradiotherapy. Chemotherapy offers the benefit of laryngeal preservation in Kaposi sarcoma involving the larynx and may be considered as a treatment option in patients with high risk of surgical intervention.